GAB2（GRB2 associated binding protein 2），癌症关联基因，基因ID：9846，该基因是grb2相关结合蛋白（gab）基因家族的成员。这些蛋白含有Pleckstrin同源性（PH）结构域，并结合SHP2酪氨酸磷酸酶和GRB2适配器蛋白。它们充当适配器，通过细胞因子和生长因子受体以及T细胞和B细胞抗原受体对刺激作出反应，传递各种信号。该基因编码的蛋白是磷脂酰肌醇-3激酶的主要激活剂，对高亲和力IgE受体的激活有反应已经描述了该基因的两个编码不同亚型的选择性剪接转录本。[由RefSeq提供，2009年11月]This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain， and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors， and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq， Nov 2009]。