CSK（C-terminal Src kinase），癌症关联基因，基因ID：1445，该基因编码的蛋白参与多种途径，包括src家族激酶的调控。它通过与蛋白酪氨酸磷酸酶（ptpn22）基因编码的蛋白结合，在t细胞活化中发挥重要作用。该蛋白也在多种底物上磷酸化C末端酪氨酸残基，包括SRC原癌基因、非受体酪氨酸激酶基因编码的蛋白质磷酸化抑制src家族酪氨酸激酶的激酶活性。该基因的内含子多态性（rs34933034）已被发现影响b细胞的活化，并与系统性红斑狼疮（sle）有关。选择性剪接导致多个转录变体[由RefSeq提供，2017年8月]The protein encoded by this gene is involved in multiple pathways， including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase， non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates， including the protein encoded by the SRC proto-oncogene， non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus er。