CREB1（cAMP responsive element binding protein 1），癌症关联基因，基因ID：1385，这个基因编码一个转录因子，它是DNA结合蛋白亮氨酸拉链家族的成员这种蛋白质以同二聚体的形式与cAMP反应元件八聚体回文结合该蛋白被几种蛋白激酶磷酸化，并诱导基因转录以响应cAMP途径的激素刺激这个基因的交替剪接导致编码不同亚型的几个转录变体[由RefSeq提供，2016年3月]This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element， an octameric palindrome. The protein is phosphorylated by several protein kinases， and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq， Mar 2016]。