CCR4（C-C motif chemokine receptor 4），癌症关联基因，基因ID：1233，该基因编码的蛋白属于g蛋白偶联受体家族。它是cc趋化因子mip-1、rantes、tarc和mcp-1的受体。趋化因子是一组小的多肽，结构上相关的分子，调节各种类型白细胞的细胞运输。趋化因子在免疫系统的发育、稳态和功能中也发挥着重要作用，它们对中枢神经系统的细胞以及参与血管生成或血管稳定的内皮细胞都有影响[由RefSeq提供，2008年7月]The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1， RANTES， TARC and MCP-1. Chemokines are a group of small polypeptide， structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development， homeostasis， and function of the immune system， and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq， Jul 2008]。