BRD2（bromodomain containing 2），癌症关联基因，基因ID：6046，该基因编码一种转录调节因子，属于bet（溴脱氧核糖和额外末端结构域）蛋白质家族。该蛋白在有丝分裂过程中与转录复合物和乙酰化染色质相结合，并通过其两个溴代氨酸选择性地与组蛋白H4的乙酰化赖氨酸-12残基结合该基因定位于6p21.3号染色体上的主要组织相容性复合体（MHC）Ⅱ类区域，但序列比较表明该蛋白不参与免疫应答这个基因与青少年肌阵挛性癫痫有关，这是一种常见的癫痫形式，在青少年时期就很明显了。已经描述了该基因的多个选择性剪接变体[由RefSeq提供，2010年12月]This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis， and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3， but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy， a common form of epilepsy that becomes apparent in adolescence. Multiple alternative。