ARHGAP29(Rho GTPase activating protein 29),癌症关联基因,基因ID:9411,RAP1是一种小的GTPase,通过效应器调节Rho GTPase信号。这些效应因子-rasip1,radil和由这个基因编码的蛋白质-转移到细胞膜上,在那里形成一个多蛋白复合物。这种复合物是Rap1诱导Rho信号抑制的必要条件该基因缺陷可能是非综合征性唇腭裂伴或不伴腭裂的原因[由RefSeq提供,2016年6月]Rap1 is a small GTPase that, through effectors, regulates Rho GTPase signaling. These effectors- Rasip1, Radil, and the protein encoded by this gene- translocate to the cell membrane, where they form a multiprotein complex. This complex is necessary for Rap1-induced inhibition of Rho signaling. Defects in this gene may be a cause of nonsyndromic cleft lip with or without cleft palate. [provided by RefSeq, Jun 2016]。