MSH5（mutS homolog 5），癌症关联基因，基因ID：4439，该基因编码muts家族的一个成员，参与dna错配修复和减数分裂重组。该蛋白类似于酿酒酵母蛋白，在减数分裂过程中参与分离保真度和交叉事件。该蛋白在促进电离辐射诱导的细胞凋亡中发挥作用。该蛋白与该家族的另一成员muts同源物4形成杂寡聚体。该基因的多态性与多种人类疾病有关，包括iga缺乏、常见的可变免疫缺陷和卵巢早衰。选择性剪接导致多个转录变体。在该基因与下游染色体6开放阅读框26（C6OF26）基因之间也存在通读转录。[由RefSeq提供，2011年2月]This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family， mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases， including IgA deficiency， common variable immunodeficiency， and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcriptio。