GSTT1(glutathione S-transferase theta 1),癌症关联基因,基因ID:2952,由该基因编码的蛋白质,谷胱甘肽s-转移酶(gst)θ1(gstt1)是一个蛋白质超家族的成员,它催化还原型谷胱甘肽与多种亲电和疏水化合物的结合。人类gst可分为五大类:alpha、mu、pi、theta和zeta。theta类包括gstt1、gstt2和gstt2b,gstt1和gstt2/gstt2b具有55%的氨基酸序列同源性,可能在人类致癌过程中起作用。gstt1基因是单倍型特异性的,38%的人群中没有gstt1基因。该基因的选择性剪接导致多个转录变体。[由RefSeq提供,2015年9月]The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. [provided by。