E2F3（E2F transcription factor 3），癌症关联基因，基因ID：1871，该基因编码一个转录因子小家族的成员，通过结合dp相互作用伙伴蛋白发挥作用。编码蛋白识别dna中的一个特定序列模体，并与视网膜母细胞瘤蛋白（prb）直接相互作用，调节细胞周期相关基因的表达。这种基因的拷贝数和活性已经在许多人类癌症中被观察到。在2号和17号染色体上有这个基因的假基因。选择性剪接导致多个转录变体。[由RefSeq提供，2013年3月]This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq， Mar 2013]。