ARID5B（AT-rich interaction domain 5B），癌症关联基因，基因ID：84159，这个基因编码了一个dna结合蛋白at-rich相互作用域家族的成员。编码的蛋白与phd指蛋白2形成组蛋白h3k9me2脱甲基酶复合物，并调节参与脂肪生成和肝脏发育的靶基因的转录。该基因还参与b淋巴细胞祖细胞的生长和分化，其单核苷酸多态性与急性淋巴细胞白血病有关。另外，已经观察到该基因编码多个亚型的剪接转录变体。[由RefSeq提供，2011年9月]This gene encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein forms a histone H3K9Me2 demethylase complex with PHD finger protein 2 and regulates the transcription of target genes involved in adipogenesis and liver development. This gene also plays a role in cell growth and differentiation of B-lymphocyte progenitors， and single nucleotide polymorphisms in this gene are associated with acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq， Sep 2011]。