CYP2A6（cytochrome P450 family 2 subfamily A member 6），癌症关联基因，基因ID：1548，这个基因，cyp2a6，编码细胞色素p450酶超家族的一个成员。细胞色素p450蛋白是一种单加氧酶，催化药物代谢和胆固醇、类固醇等脂类的合成。该蛋白定位于内质网，由苯巴比妥诱导表达。这种酶是已知的羟基香豆素，也代谢尼古丁，黄曲霉毒素B1，亚硝胺和一些药物。具有某些等位基因变异的个体被认为具有不良的代谢表型，这意味着他们不能有效地代谢香豆素或尼古丁。该基因是来自19q染色体cyp2a、cyp2b和cyp2f亚家族的一大簇细胞色素p450基因的一部分，该基因以前被称为cyp2a3，但现在已改名为cyp2a6。[由RefSeq提供，2008年7月]This gene， CYP2A6， encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol， steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin， and also metabolizes nicotine， aflatoxin B1， nitrosamines， and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype， meaning they do not efficiently metabol。