CYLD（CYLD lysine 63 deubiquitinase），癌症关联基因，基因ID：1540，该基因编码一种细胞质蛋白，具有三个细胞骨架相关蛋白-甘氨酸保守（cap-gly）结构域，作为一种去氢酶。该基因突变与圆筒状瘤、多发性家族性毛发上皮瘤和brooke-spiegler综合征有关。交替转录剪接变体，编码不同的亚型，已经被描述出来。[由RefSeq提供，2008年7月]This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis， multiple familial trichoepithelioma， and Brooke-Spiegler syndrome. Alternate transcriptional splice variants， encoding different isoforms， have been characterized. [provided by RefSeq， Jul 2008]。