MAP2K4（mitogen-activated protein kinase kinase 4），癌症关联基因，基因ID：6416，这个基因编码有丝分裂原活化蛋白激酶（mapk）家族的一个成员。这个家族的成员作为多种生化信号的整合点，参与多种细胞过程，如增殖、分化、转录调节和发育。它们形成一个由mapkks、mapkks和mapks组成的三层信令模块。该蛋白在丝氨酸和苏氨酸残基处被mapkks磷酸化，随后在苏氨酸和酪氨酸残基处磷酸化下游mapk靶点。据报道，小鼠体内的一种类似蛋白质在肝脏器官发生中起作用。该基因的一个假基因位于x染色体的长臂上。选择性剪接导致多个转录变体。[由RefSeq提供，2013年7月]This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation， differentiation， transcription regulation， and development. They form a three-tiered signaling module composed of MAPKKKs， MAPKKs， and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A。