TBK1（TANK binding kinase 1），癌症关联基因，基因ID：29110，蛋白的NF-kappa-b（nfkb）复合物被I-kappa-b（ikb）蛋白抑制，通过将其捕获在细胞质中使nfkb失活。IKB激酶对IKB蛋白丝氨酸残基的磷酸化标记它们通过泛素化途径被破坏，从而允许NFKB复合体的活化和核易位。该基因编码的蛋白质类似于IKB激酶，可以调节NFKB的激活以响应某些生长因子。The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins， which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway， thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors.关联癌症：黑色素瘤。关联化疗药物：AZ909，司美替尼。