IRS2（insulin receptor substrate 2），癌症关联基因，基因ID：8660，该基因编码胰岛素受体底物2，这是一种胞质信号分子，通过充当不同受体酪氨酸激酶和下游效应器之间的分子接头来调节胰岛素、胰岛素样生长因子1和其他细胞因子的作用。这种基因的产物在受体刺激时被胰岛素受体酪氨酸激酶磷酸化，在IL4治疗后被白细胞介素4受体相关激酶磷酸化。This gene encodes the insulin receptor substrate 2， a cytoplasmic signaling molecule that mediates effects of insulin， insulin-like growth factor 1， and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation， as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.关联癌症：结直肠癌。关联化疗药物：BMS-754807。