EPHB4（EPH receptor B4），癌症关联基因，基因ID：2050，肾上腺素受体及其配体，肾上腺素，介导许多发育过程，特别是在神经系统。根据其结构和序列关系，肾素被分为通过糖基磷脂酰肌醇连接锚定在膜上的肾素-A（efna）类和作为跨膜蛋白的肾素-B（efnb）类。EPH受体家族根据其胞外结构域序列的相似性及其与肾素A和肾素B配体结合的亲缘关系分为2组。肾上腺素受体构成受体酪氨酸激酶（RTK）家族的最大亚群。该基因编码的蛋白质与肾素B2结合，在血管发育中起重要作用。Ephrin receptors and their ligands， the ephrins， mediate numerous developmental processes， particularly in the nervous system. Based on their structures and sequence relationships， ephrins are divided into the ephrin-A (EFNA) class， which are anchored to the membrane by a glycosylphosphatidylinositol linkage， and the ephrin-B (EFNB) class， which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and pla。