BIRC5（baculoviral IAP repeat containing 5），癌症关联基因，基因ID：332，该基因是凋亡抑制因子（IAP）基因家族的成员，其编码抑制凋亡细胞死亡的负调节蛋白。IAP家族成员通常包含多个杆状病毒IAP重复序列（BIR）域，但该基因仅编码一个BIR域的蛋白质。编码蛋白也缺乏C端环指结构域。在胎儿发育和大多数肿瘤中基因表达较高，而在成人组织中表达较低。另外，还发现了编码该基因不同亚型的剪接转录变体。This gene is a member of the inhibitor of apoptosis (IAP) gene family， which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains， but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors， yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.关联癌症：Her2受体阳性乳腺癌，非小细胞肺癌。关联化疗药物：PLATINUM，Taxane，曲妥珠单抗。