BRD4（bromodomain containing 4），癌症关联基因，基因ID：23476，该基因编码的蛋白质与小鼠蛋白MCAP（有丝分裂过程中与染色体相关）和人类Ring3蛋白（丝氨酸/苏氨酸激酶）同源。每一种蛋白质都包含两个溴域，一个保守的序列基序，可能参与染色质靶向。该基因被认为是T（15；19）易位的19号染色体靶基因（q13；p13.1），它定义了年轻人的上呼吸道癌。已经描述了两个选择性剪接转录变体。The protein encoded by this gene is homologous to the murine protein MCAP， which associates with chromosomes during mitosis， and to the human RING3 protein， a serine/threonine kinase. Each of these proteins contains two bromodomains， a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1)， which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described.关联癌症：透明细胞肾细胞癌，坚果中线癌。关联化疗药物：比拉瑞塞，JQ1。