IGF2（insulin like growth factor 2），癌症关联基因，基因ID：3481，该基因编码多肽生长因子胰岛素家族的一个成员，参与发育和生长。它是一个印记基因，仅从父系等位基因表达，该位点的表观遗传变化与Wilms肿瘤、Beckwith-Wiedemann综合征、横纹肌肉瘤和Silver-Russell综合征有关。存在一个通读的INS-IGF2基因，其5'区与INS基因重叠，3'区与该基因重叠。另外，还发现了编码不同亚型的剪接转录变体。This gene encodes a member of the insulin family of polypeptide growth factors， which are involved in development and growth. It is an imprinted gene， expressed only from the paternal allele， and epigenetic changes at this locus are associated with Wilms tumour， Beckwith-Wiedemann syndrome， rhabdomyosarcoma， and Silver-Russell syndrome. A read-through INS-IGF2 gene exists， whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.关联癌症：卵巢癌，胰腺腺癌，前列腺癌。关联化疗药物：卡巴他赛，加尼妥单抗，林西替尼。