ABCC1（ATP binding cassette subfamily C member 1），癌症关联基因，基因ID：4363，该基因编码的蛋白质是atp结合盒（abc）转运蛋白超家族的成员。abc蛋白通过细胞外和细胞内的膜运输各种分子。abc基因分为七个不同的亚家族（abc1，mdr/tap，mrp，ald，oabp，gcn20，white）。这种全转运蛋白是mrp亚家族的一员，参与多药耐药。该蛋白作为一种多特异性有机阴离子转运蛋白，以氧化戊二酮、半胱氨酸白三烯和活化的黄曲霉毒素b1为底物。这种蛋白质还运输葡萄糖醛酸和类固醇激素和胆盐的硫酸盐结合物。该基因的选择性剪接变体已经被描述，但其全长性质未知。[由RefSeq提供，2012年4月]The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1， MDR/TAP， MRP， ALD， OABP， GCN20， White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter， with oxidized glutatione， cysteinyl leukotrienes， and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of st。