TPH1（tryptophan hydroxylase 1），癌症关联基因，基因ID：7166，这个基因编码芳香族氨基酸羟化酶家族的一个成员编码蛋白催化5-羟色胺生物合成的第一步和限速步骤，5-羟色胺是一种重要的激素和神经递质该基因的突变与多种疾病和疾病的风险升高有关，包括精神分裂症、躯体焦虑、愤怒相关特征、双相情感障碍、自杀行为、成瘾等。[ RefSeq，APR 2009 ]This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin， an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders， including schizophrenia， somatic anxiety， anger-related traits， bipolar disorder， suicidal behavior， addictions， and others.[provided by RefSeq， Apr 2009]。