TGM2（transglutaminase 2），癌症关联基因，基因ID：7052，转谷氨酰胺酶是通过epsilonγ-谷氨酰赖氨酸等肽键催化蛋白质交联的酶虽然转谷氨酰胺酶的一级结构并不保守，但它们的活性位点都具有相同的氨基酸序列，并且它们的活性是钙依赖性的。该基因编码的蛋白质作为单体，由维甲酸诱导，似乎参与了细胞凋亡最后，编码的蛋白质是与乳糜泻有关的自身抗原已经发现了两个编码不同亚型的转录变体。[由RefSeq提供，2008年7月]Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved， they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer， is induced by retinoic acid， and appears to be involved in apoptosis. Finally， the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq， Jul 2008]。