PTPRU(protein tyrosine phosphatase receptor type U),癌症关联基因,基因ID:10076,该基因编码的蛋白是蛋白酪氨酸磷酸酶(PTP)家族的一员众所周知,PTPs是调节细胞生长、分化、有丝分裂周期和癌基因转化等多种细胞过程的信号分子该ptp具有胞外区、单个跨膜区和两个串联的胞内催化区,因此代表一种受体型ptp。细胞外区域包含一个meprin-a5抗原ptp(mam)结构域、ig样和纤维粘连蛋白iii样重复序列。这种ptp被认为在细胞识别和粘附中起作用。对小鼠类似基因的研究表明,ptp在早期神经发育中的作用。据报道,该基因在Jurkat T淋巴瘤细胞中的表达受肉豆蔻酸佛波酯(PMA)或钙离子载体的调控另一种剪接的转录变体已被报道[由RefSeq提供,2010年8月]The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in 。