HNF1B（HNF1 homeobox B），癌症关联基因，基因ID：6928，这个基因编码一个含有转录因子超家族的同源结构域成员。该蛋白以同二聚体或异二聚体的形式与DNA结合，并与相关蛋白肝细胞核因子1-α结合该基因在肾单位发育中发挥作用，并调节胚胎胰腺的发育。该基因突变可导致肾囊肿、糖尿病综合征和非胰岛素依赖型糖尿病，在某些癌症中该基因的表达也发生改变已发现该基因编码不同亚型的多个转录变体。[由RefSeq提供，2009年9月]This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer， or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development， and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus， and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq， Sep 2009]。