GNRHR（gonadotropin releasing hormone receptor），癌症关联基因，基因ID：2798，该基因编码1型促性腺激素释放激素受体该受体是七个跨膜g蛋白偶联受体（gpcr）家族的成员。它在垂体促性腺激素细胞以及淋巴细胞、乳腺、卵巢和前列腺的表面表达。在促性腺激素释放激素结合后，受体与激活磷脂酰肌醇钙第二信使系统的G蛋白结合。受体的激活最终导致促性腺激素黄体生成素（LH）和卵泡刺激素（FSH）的释放该基因的缺陷是导致低促性腺激素性性腺功能减退（hh）的原因之一。选择性剪接导致编码不同亚型的多个转录变体该基因在5'区有18个以上的转录起始位点，在3'区有多个polya信号。[由RefSeq提供，2008年7月]This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane， G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes， breast， ovary， and prostate. Following binding of gonadotropin-releasing hormone， the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hyp。