DCAF12L2(DDB1 and CUL4 associated factor 12 like 2),癌症关联基因,基因ID:340578,这个基因编码WD重复蛋白家族的一个成员。WD重复是由Gly His和Trp ASP(GH-WD)包围的大约40个氨基酸的最小保守区域,这可能促进异源三聚体或多蛋白复合物的形成。该家族成员参与多种细胞过程,包括细胞周期进程、信号转导、凋亡和基因调控这个基因似乎代表了位于9号染色体上的一个相关的多外显子基因的无内含子的反转录。然而,这个无内含子基因的cds保持完整,它在其他哺乳动物物种中是保守的,它被认为是转录的,因此它被认为编码一种功能蛋白。[由RefSeq提供,2010年5月]This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multi-protein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene appears to represent an intronless retrocopy of a related multi-exon gene located on chromosome 9. However, the CDS of this intronless gene remains intact, it is conserved in other mammalian species, it i。