CHFR（checkpoint with forkhead and ring finger domains），癌症关联基因，基因ID：55743，该基因编码一种E3泛素蛋白连接酶，维持调控细胞周期进入有丝分裂的前相检查点，因此可能在细胞周期进展和肿瘤发生中起关键作用编码的蛋白质具有一个N末端叉头相关结构域、一个中央无名指结构域和一个富含半胱氨酸的C末端区域。已经描述了编码不同蛋白质亚型的选择性剪接转录变体[由RefSeq提供，2014年3月]This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and， therefore， may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain， a central RING-finger domain， and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq， Mar 2014]。