ADAMTS6（ADAM metallopeptidase with thrombospondin type 1 motif 6），癌症关联基因，基因ID：11174，该基因编码ADAMTS（一种具有血小板反应蛋白基序的去整合素和金属蛋白酶）蛋白家族的成员。家族成员共享几个不同的蛋白质模块，包括一个预肽区、一个金属蛋白酶结构域、一个类去整合素结构域和一个血栓反应蛋白1型（TS）基序这个家族的个别成员在c-末端ts基序的数目上不同，有些成员具有独特的c-末端结构域。编码的前蛋白经蛋白质水解处理生成成熟酶。这种基因的表达可能受细胞因子TNFα的调节[由RefSeq提供，2016年3月]This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules， including a propeptide region， a metalloproteinase domain， a disintegrin-like domain， and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs， and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Expression of this gene may be regulated by the cytokine TNF-alpha. [provided by RefSeq， Mar 2016]。