ADGRG4（adhesion G protein-coupled receptor G4），癌症关联基因，基因ID：139378，该基因编码一个G蛋白偶联受体，属于参与多种生理功能的多种膜蛋白大家族这个超家族的成员具有一个特征性的7-跨膜结构域基序。这个家族成员的配体是未知的，因此它是一个孤儿受体。该受体在正常肠嗜铬细胞和胃肠神经内分泌癌细胞中均有表达，因此被认为是一种新的免疫治疗生物标志物或靶点。[由RefSeq提供，2010年5月]This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The ligand for this family member is unknown， and it is therefore an orphan receptor. This receptor is known to be expressed in normal enterochromaffin cells and in gastrointestinal neuroendocrine carcinoma cells， and it is therefore considered to be a novel biomarker or target for immunotherapy. [provided by RefSeq， May 2010]。