RAD21（RAD21 cohesin complex component），癌症关联基因，基因ID：5885，该基因编码的蛋白质与pombe-rad21裂殖酵母的基因产物高度相似，该基因参与dna双链断裂的修复以及有丝分裂过程中的染色单体结合。该蛋白是一种核磷酸化蛋白，在细胞周期m期发生高磷酸化。这种蛋白与着丝粒区有丝分裂染色质的高度调节关系表明它在有丝分裂细胞中的姐妹染色单体结合中起作用。[由RefSeq提供，2008年7月]The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21， a gene involved in the repair of DNA double-strand breaks， as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein， which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells. [provided by RefSeq， Jul 2008]。