XPA（XPA， DNA damage recognition and repair factor），癌症关联基因，基因ID：7507，该基因编码锌指蛋白，在核苷酸切除修复（ner）中起中心作用，ner是一种特殊类型的dna修复。ner负责修复由化学致癌物和化学治疗药物引起的uv辐射引起的光产物和dna加合物。编码的蛋白质与dna和一些ner蛋白相互作用，在dna损伤部位作为组装ner切口复合体的支架。该基因突变导致着色性干皮病互补组（xp-a），一种常染色体隐性皮肤病，对阳光过敏，增加皮肤癌的风险。[由RefSeq提供，2017年8月]This gene encodes a zinc finger protein plays a central role in nucleotide excision repair (NER)， a specialized type of DNA repair. NER is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens and chemotherapeutic drugs. The encoded protein interacts with DNA and several NER proteins， acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in this gene cause Xeroderma pigmentosum complementation group A (XP-A)， an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer. [provided by RefSeq， Aug 2017]。