PPM1D（protein phosphatase， Mg2+/Mn2+ dependent 1D），癌症关联基因，基因ID：8493，该基因编码的蛋白是ser/thr蛋白磷酸酶pp2c家族的成员。pp2c家族成员是细胞应激反应途径的负调控因子。该基因的表达在不同的环境胁迫下以p53依赖的方式诱导。在肿瘤抑制蛋白tp53/p53诱导下，这种磷酸酶负性调节p38-map激酶mapk/p38的活性，从而降低p53的磷酸化，进而抑制p53介导的转录和凋亡。因此，这种磷酸酶介导p38-p53信号的反馈调节，有助于生长抑制和抑制应激诱导的凋亡。该基因位于已知在乳腺癌中被扩增的染色体区域。在乳腺癌细胞系和原发性乳腺肿瘤中都检测到该基因的扩增，这表明该基因在乳腺癌的发生发展中起着一定的作用。[由RefSeq提供，2008年7月]The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53， this phosphatase negatively regulates the activity of p38 MAP kinase， MAPK/p38， through which it reduces the phosphorylation of p53， and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a。