EPHA4（EPH receptor A4），癌症关联基因，基因ID：2043，该基因属于酪氨酸蛋白激酶家族的肾上腺素受体亚家族。eph和eph相关受体参与了发育事件的调节，特别是在神经系统中。eph亚家族的受体通常有一个单一的激酶结构域和一个胞外区域，包含一个富含cys的结构域和2个纤维连接蛋白iii型重复序列。根据其胞外结构域序列的相似性和结合ephrin-a和ephrin-b配体的亲和力，ephrin受体可分为两类。已发现该基因编码不同亚型的多个转录变体。[由RefSeq提供，2015年1月]This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events， particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq， Jan 2015]。