PDK1（pyruvate dehydrogenase kinase 1），癌症关联基因，基因ID：5163，丙酮酸脱氢酶（pdh）是一种催化丙酮酸氧化脱羧的线粒体多酶复合物，是哺乳动物体内调节碳水化合物燃料稳态的主要酶之一。酶活性由磷酸化/去磷酸化循环调节。丙酮酸脱氢酶激酶（pdk）磷酸化pdh导致失活。已发现该基因的多个选择性剪接转录变体。[由RefSeq提供，2013年6月]Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq， Jun 2013]。