PLCG2（phospholipase C gamma 2），癌症关联基因，基因ID：5336，该基因编码的蛋白是一种跨膜信号酶，利用钙作为辅因子催化1-磷脂酰-1d-肌醇4，5-二磷酸转化为1d-肌醇1，4，5-三磷酸（IP3）和二酰甘油（DAG）。IP3和DAG是第二信使分子，对通过细胞膜传递生长因子受体和免疫系统受体的信号很重要。该基因突变见于自身炎症、抗体缺乏、免疫失调综合征和家族性感冒自身炎症综合征3。The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4，5-bisphosphate to 1D-myo-inositol 1，4，5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation， antibody deficiency， and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3.关联癌症：慢性淋巴细胞白血病。