HDAC2（histone deacetylase 2），癌症关联基因，基因ID：3066，该基因产物属于组蛋白脱乙酰基酶家族。组蛋白脱乙酰基酶通过形成大的多蛋白复合物起作用，并负责核心组蛋白（H2A、H2B、H3和H4）N端赖氨酸残基的脱乙酰化。这种蛋白通过与许多不同的蛋白质结合形成转录抑制复合物，包括哺乳动物锌指转录因子YY1。因此，它在转录调控、细胞周期进展和发育事件中起着重要作用。选择性剪接导致多个转录变体。This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes， and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A， H2B， H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins， including YY1， a mammalian zinc-finger transcription factor. Thus， it plays an important role in transcriptional regulation， cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.关联癌症：肾细胞癌。关联化疗药物：艾贝司他，帕唑帕尼，培唑帕尼。