KLLN（killin， p53-regulated DNA replication inhibitor），癌症关联基因，基因ID：100144748，这种无内含子基因编码的蛋白质存在于细胞核中，在那里它可以抑制DNA合成，促进S相停滞，并与凋亡相结合。这种DNA结合蛋白的表达被转录因子p53上调。The protein encoded by this intronless gene is found in the nucleus， where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53.关联癌症：乳腺癌，肾细胞癌。