FLCN（folliculin），癌症关联基因，基因ID：201163，该基因位于17号染色体的Smith-Magenis综合征区域。该基因突变与Birt-Hogg-Dube综合征有关，后者以纤维滤泡瘤、肾肿瘤、肺囊肿和气胸为特征。该基因的选择性剪接导致编码不同亚型的两个转录变体。This gene is located within the Smith-Magenis syndrome region on chromosome 17. Mutations in this gene are associated with Birt-Hogg-Dube syndrome， which is characterized by fibrofolliculomas， renal tumors， lung cysts， and pneumothorax. Alternative splicing of this gene results in two transcript variants encoding different isoforms.关联癌症：乳头状肾细胞癌。关联化疗药物：依维莫司，Sirolimus [USAN:BAN:INN]。