ERCC2（ERCC excision repair 2， TFIIH core complex helicase subunit），癌症关联基因，基因ID：2068，核苷酸切除修复途径是修复DNA损伤的机制。该基因编码的蛋白参与转录偶联核苷酸切除修复，是基础转录因子btf2/tfiih复合物的一个不可分割的成员。该基因产物具有ATP依赖性DNA解旋酶活性，属于解旋酶的RAD3/XPD亚家族。这种基因的缺陷可导致三种不同的疾病，即癌症易发综合征着色性干皮病互补组D、毛细胞增生症和Cockayne综合征。另外，还发现了编码不同亚型的剪接转录变体。The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders， the cancer-prone syndrome xeroderma pigmentosum complementation group D， trichothiodystrophy， and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.关联癌症：非小细胞肺癌，骨肉瘤。