DNMT3A（DNA methyltransferase 3 alpha），癌症关联基因，基因ID：1788，CpG甲基化是一种表观遗传修饰，对胚胎发育、印记和X染色体失活具有重要意义。对小鼠的研究表明，DNA甲基化是哺乳动物发育所必需的。这个基因编码一种DNA甲基转移酶，被认为在从头甲基化中起作用，而不是维持甲基化。该蛋白定位于细胞质和细胞核，其表达受发育调节。CpG methylation is an epigenetic modification that is important for embryonic development， imprinting， and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation， rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.关联癌症：急性白血病，急性髓系白血病，癌症，骨髓增生异常综合征，T细胞急性淋巴细胞白血病。关联化疗药物：阿特珠单抗，阿替利珠单抗，Decitabine，纳武单抗，纳武利尤单抗，派姆单抗，帕博利珠单抗。