IL7R(interleukin 7 receptor),癌症关联基因,基因ID:3575,该基因编码的蛋白质是白细胞介素7(IL7)的受体。这种受体的功能需要白细胞介素2受体γ链(il2rg),它是多种细胞因子受体(包括白细胞介素2、4、7、9和15)共有的一种γ链。该蛋白在淋巴细胞发育过程中对V(D)J重组起到关键作用。该基因的缺陷可能与严重联合免疫缺陷(SCID)有关。另外,还发现了拼接转录变体。The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found.关联癌症:小儿B淋巴细胞白血病,T细胞急性淋巴细胞白血病。