PTPRJ（protein tyrosine phosphatase receptor type J），癌症关联基因，基因ID：5795，该基因编码的蛋白是蛋白酪氨酸磷酸酶（ptp）家族的一员。众所周知，ptps是调节多种细胞过程的信号分子，包括细胞生长、分化、有丝分裂周期和癌基因转化。该ptp具有含有5个纤维粘连蛋白iii型重复序列的胞外区域、单个跨膜区域和单个胞浆内催化结构域，因此代表ptp受体类型。该蛋白存在于所有造血系中，可能通过干扰磷脂酶cγ1的磷酸化和激活t细胞的连接蛋白来负调控t细胞受体信号。该蛋白也能使pdgfβ受体去磷酸化，可能参与uv诱导的信号转导。已发现该基因编码不同亚型的多个转录变体。[由RefSeq提供，2008年7月]The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes， including cell growth， differentiation， mitotic cycle， and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats， a single transmembrane region， and a single intracytoplasmic catalytic domain， and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages， and was shown to negatively regulate T cell receptor signaling possibly through interferin。