POT1（protection of telomeres 1），癌症关联基因，基因ID：25913，这个基因是端粒家族的成员，编码一种参与端粒维持的核蛋白。具体来说，这种蛋白作为一种多蛋白复合物的成员发挥作用，该复合物结合端粒的ttagg重复序列，调节端粒长度，保护染色体末端不受非法重组、灾难性染色体不稳定和异常染色体分离的影响。该基因转录表达的增加与胃癌的发生及其进展有关。另外，还描述了拼接转录变体。This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically， this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres， regulating telomere length and protecting chromosome ends from illegitimate recombination， catastrophic chromosome instability， and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.关联癌症：慢性淋巴细胞白血病。