STAT1（signal transducer and activator of transcription 1），癌症关联基因，基因ID：6772，这个基因编码的蛋白质是stat蛋白家族的一员。在对细胞因子和生长因子的反应中，stat家族成员被受体相关的激酶磷酸化，然后形成homo-或异二聚体，在那里它们作为转录激活因子转移到细胞核。该蛋白可被多种配体激活，包括干扰素α、干扰素γ、egf、pdgf和il6。这种蛋白质介导多种基因的表达，这被认为是对不同细胞刺激和病原体的细胞活力的重要反应。已经描述了编码不同亚型的两个选择性剪接转录变体[由RefSeq提供，2008年7月]The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors， STAT family members are phosphorylated by the receptor associated kinases， and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha， interferon-gamma， EGF， PDGF and IL6. This protein mediates the expression of a variety of genes， which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isofor。