ANK2（ankyrin 2），癌症关联基因，基因ID：287，这个基因编码一个蛋白的ankyrin家族的成员，该家族将完整的膜蛋白与潜在的spectrin肌动蛋白细胞骨架连接起来锚蛋白在细胞运动、活化、增殖、接触和维持特殊膜结构等方面发挥着重要作用。大多数锚蛋白通常由三个结构域组成：含有多个锚蛋白重复序列的氨基末端域；具有高度保守的谱蛋白结合域的中心区域；以及最不保守且易变异的羧基末端调节域。该基因编码的蛋白质是心肌细胞na/ca交换蛋白1的靶向性和稳定性所必需的。该基因突变导致长qt综合征4和心律失常综合征。已经描述了编码不同亚型的多个转录变体。[由RefSeq提供，2011年12月]This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility， activation， proliferation， contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and 。